Current oncology clinical trials. Volume 43; Issue 2; January 10, 2025; .

Current oncology clinical trials “Clinical trials are essential to be able to identify better treatments for patients with all tumor types,” says Funda Meric-Bernstam, M. About Clinical Trials. show a new drug is more effective or safer than the current treatment, a new drug application (NDA) is submitted to the Food and Drug Administration (FDA) for approval. An external control arm data source should be temporally and clinically relevant to the investigational arm to minimize bias, Current Oncology Clinical Trials. With an unprecedented number of new investigational agents and companies in immuno-oncology (IO), it has been difficult to track and understand the current IO agents in clinical development and Honoraria: WebMD/Medscape (less than $10,000 USD in a single calendar year), MJH Associates (less than $10,000 USD in a single calendar year), Clinical Care Options (less than $10,000 USD in a single calendar year), Cancer Expert Now (less than $10,000 USD in a single calendar year), Clinical Care Options (less than $10,000 USD in a single calendar year) Current Oncology Reports - The AXL signaling pathway is associated with tumor growth as well as poor prognosis in cancer. Such trials help scientists answer questions about new cancer therapies, including: what diseases should they be used for? Oncology Drug Pipeline & Cancer Clinical Trials. It means to enroll more Black Americans in cancer clinical trials to try to eliminate the sampling bias. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase Methods: The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials. External control arm data may be derived from prior clinical trial data (individual or pooled), or observational, real-world data (RWD), such as from registries, electronic health records (EHRs), and medical or pharmacy claims (see Figure 1). Alexia Iasonos, PhD, is currently an Attending Biostatistician and Director of Clinical Research Development at Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics. We conclude with a discussion of outstanding issues and Core Patient-Reported Outcomes in Cancer Clinical Trials: Final: October 2024: Content current as of: 12/01/2024. CytoSleuth Quiz. The review extends beyond CDK2i to encompass novel emerging CDK4 inhibitors, combined CDK2/4/6 inhibitors, and the well-known pan-CDK inhibitors including those specifically Current volunteers; National Volunteer Week 2024; Hospital > Care Programs > Odette Cancer Program > Clinical trials. There are several types of cancer clinical trials. 56 This should be expanded, so a greater proportion of oncologists are involved in conducting clinical research trials. However, current indications suggest that participation in clinical trials is the exception rather than the rule both for patients and for physicians. This review focuses on how HIF inhibitors could be applied in conjunction with current cancer treatments, including those now being evaluated in clinical trials, to usher 1 EARLY PHASE ONCOLOGY CLINICAL TRIALS IN ASIA. Panels A–C show the number of clinical trials in breast cancer since early 2000, by immunotherapeutic approach (A), by trial setting (B), and by trial phase (C). Gynecologic Cytology. Current patient. gov will bring you to a comprehensive list of the current U. Filter this list of studies by location, status and more. , J Control Release , 2015 and Francisco Rodriguez, et al. Therapeutic cancer vaccines based on mRNA are well tolerated, and the inherent advantage in ease of production, which rivals the best available conventional vaccine manufacture methods, Immunotherapies attempt to harness the innate and adaptive immune system to attack cancer cells. The ORR is valuable for clinical decision making in routine practice and a An official website of the United States government Menu. Until 2013, Phase 1 trials in oncology had a single, simple The Current Status of Oncology Clinical Trials in Africa. They test new therapies, treatment approaches, and diagnostic or Clinical trials play a critical role in discovering new treatments, but the path to regulatory approval can be cumbersome and time consuming. They test new therapies, treatment approaches, and diagnostic or screening methods. About Us; Work With Us: Careers In Trial Management; Patient and Public Involvement & Engagement; Current Trials; Trials in Set Up; Completed Trials; Study with Us. Nevertheless, ethical or feasibility issues can hinder the randomization process in oncology clinical trials. gov. In Cambridge, Professor Rebecca Fitzgerald is running a trial called BEST4. doi: 10. Dear Colleagues, I am pleased to announce a Special Issue in Current Oncology, titled "Advancements in Clinical Trials in Oncology: Design, Enrichment, Safety, Operations, Patient Centricity, and Endpoints", for which I am honored to serve as the Guest Editor. 460 studies in Cancer (open studies only). A Study to Evaluate Rectal Cancer with Diffusion-Weighted and Dynamic Contrast Enhanced Perfusion-Weighted Magnetic Resonance Imaging. 1 Since early systematic clinical applications of immunotherapy in oncology, such as the use of Relative to other diseases, cancer has the largest number of clinically relevant mutations and the most multimodality treatment options, in part because of advances in translational research and the conduct of clinical The outcomes of phase II and III clinical trials of direct HIF inhibitors in the treatment of cancer will be reviewed. They also help to find out if it is better than the current treatment or helps you feel better. The included trials were conducted between January 2013 and December 2022 and were examined for key characteristics, including outcome measures, interventions, sample sizes, and study design, different cancer types, and Landscape of Immuno-Oncology Drug Development. Conducting clinical trials in the region is important to assess efficacy and safety of oncology medications in the specific population (response to drugs can be impacted Oncology clinical trial starts reached historically high levels in 2020, up 60% from 2015, and focused mostly on rare cancer indications. We reviewed the use of RPh2 designs and give comments on future directions. 004. We support a collaborative network of researchers, physicians, scientists and statisticians internationally recognized for finding the treatments that give people with cancer longer, better Cancer clinical trials are highly complex and represent a major research undertaking. gov for a 20-year period (1990–2020) through a systematic analysis of registered trials. clinicalTrials. Search by disease site group, disease location or by keyword or phrase. The ability to translate scientific discoveries into clinical advances relies on a robust clinical trials infrastructure, which is largely dependent on a critical mass of patients and physicians willing to participate in clinical trials. Hundreds of new and promising cancer immunotherapy treatments are only available to patients in clinical trials. Types of clinical trials. Please search by selecting cancer type and cancer location or by typing in a keyword (for example: prostate). A thorough search for clinical trials related to LB in cancer, on ClinicalTrials. They must be proven safe and effective before they are approved by Health Canada. Learn more about your options. It has a range of information and resources to help you understand how clinical trials work and allows you to easily search for current trials to discuss with your doctor. ctrv. The Commission on Cancer is a consortium of cancer programs that requires member institutions to submit accreditation information every 3 The review of clinical trials is focused on the applications of the CRISPR/Cas systems in the treatment of cancer, hematological, endocrine, and immune system diseases, as well as in diagnostics. 1–3 However, older patients are vastly underrepresented in clinical trials that set the standards for the efficacy and safety of cancer treatments. Many of these groups also have a phone number you can call for help with your search. It includes information on You may be interested in finding out generally about current research. 1 Within 10 years after RNA-targeted therapeutics in cancer clinical trials: Current status and future directions Cancer Treat Rev. Call 855-776-0015 (toll-free) for information today. ASCO's Clinical Cancer Advances report highlights current trends in the field and identifies cancer research priorities that have great potential to advance progress against cancer. Italy. This systematic review assessed design and outcomes of trials focused on this patient population. Therapeutic advances for glioblastoma have been minimal over the past 2 decades. Adults: 800-525-2225. About the Journal. Current status of clinical trials of innovative and novel strategies of cancer therapy. Oncology Center of Excellence Who We Are - Oncology Center of Excellence Purpose: Randomized phase II (RPh2) designs are popular in cancer clinical trials because of the smaller sample size requirements when multiple treatments are being evaluated. About Us; Work With Us: Careers In Trial Management; Work With Us: Information for Investigators and Commercial Organisations; Information for Patients, their Families and Carers; Patient and Public Involvement & Engagement; Current Initially reported in Journal of Clinical Oncology in 2019, 1 the ARCHES trial compared the addition of enzalutamide or placebo with androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer (mHSPC). About Current Oncology Aims. The The specific aims and overall purpose of Phase 1 clinical trials have undergone substantial changes over the past several years. Lerapolturev leverages multiple, unique mechanisms of action to activate a systemic antitumor response to fight cancer. The Canadian Cancer Trials Group (CCTG) supports national and international multicentre phase I-III cancer clinical research trials aimed at improving the survival and quality of life of cancer patients across all cancer types. Differences in study characteristics such as design, study phase, randomization, masking, purpose of study, main outcomes, gender, Current Oncology, an international, peer-reviewed Open Access journal. The lack of inclusion of low-income and marginalized populations limits generalizability of the critical data guiding novel therapeutics and interventions This page tells you how you can find a clinical trial. Recent findings: The HIF signaling pathway is activated by tumor-induced hypoxia or by inactivating mutations of the VHL gene. Clinical trials are cancer research studies that give our patients the opportunity to receive tomorrow’s treatments today. Our clinical trials program is one of the largest in veterinary oncology and is supported by seven dedicated staff members. The UCD Cancer Trials Cluster delivers cutting edge cancer clinical trials, translational research, and survivorship studies to people with cancer in Ireland. More than 700 companies are involved. This study aims to comprehensively review the reporting of race and ethnicity data and the representation of race Urban India has a good oncology clinical trial infrastructure with large state-of-the-art hospitals and integrated specialty laboratories in larger cities. The format is "NCT" followed by an 8-digit number (for example, Learn about the purpose and importance of clinical trials, including the different types of clinical trials used in cancer research. Expert Bayesian methods had established a foothold in developing therapies in oncology trials. All empirical studies using patient ratings published in the Journal of Clinical Oncology from 1992 to 1996 were identified. 1016/j. (CRM), has been generalized and expanded to create designs for many complex settings that occur in early-phase oncology trials. The number of trial sites for liver cancer was not significantly higher for Asia, even though the incidence of the disease is much higher in this region. Oncologists have been provided with an unprecedented opportunity to conduct clinical trials that offer both advantages and challenges. In late 2023, we saw the first-ever approval of CRISPR-based medicine: Casgevy, a cure for sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). Topics. Current Clinical Trials. D. Each type of trial is designed to answer different research questions and will help researchers learn things that can help people in the future. The primary focus of the Cooperative Group Program is large, definitive, The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway regulates proliferation, survival and metabolism, and its dysregulation is one of the most frequent oncogenic events across human malignancies. Our strong pipeline—one of the most robust in the industry—includes biologics, small molecules, immunotherapies, and biosimilars, and is centered on exploring a wide array of It is a remarkable time for the development of CRISPR-based therapies. Given the region’s demographic significance, we sought to compare However, there are still significant gaps, including a lack of oncology clinical trials. Background: While accounting for 40% of the cancer population, older adults are underrepresented in clinical trials. Common adverse events included fatigue Background: Similar to other regions of the world, cancer incidence in Middle East and North Africa (MENA) is rising, which has been attributed to increased life expectancy and adoption of western lifestyle habits. 53, 67 In addition, prolonged stable disease has been observed in a variety of pediatric and adult solid tumors. There are several websites that give details about clinical trials for all types of cancer. They require hundreds of steps with numerous decision points and there are multilayered and iterative review processes because multiple oversight bodies have jurisdiction over a trial. Design: The trial design, statistical properties, conduct, data analysis, results, and reporting were examined in As new immunotherapeutic agents are being rapidly adopted in many cancers, including head and neck cancer, the National Cancer Institute sponsored a clinical trial planning meeting to identify opportunities for developing phase II and III trials testing immunotherapy in different stages of NPC. clinical trials involving cancer nanotechnology. Clinical trials help to find out if a new treatment or procedure is safe. Here, we provide an overview of recent developments in the field of oligonucleotide therapeutics in oncology, review current clinical trials, and discuss associated challenges. Among all the clinical trials, only trials addressing single disease sites of breast, prostate, colorectal, or lung (BPCRL) cancer were included in the age disparities analysis. Methods: We identified clinical trials posted on the ClinicalTrials. The report, now in its 16th edition, is developed by a 26-member editorial board of experts in a range of cancer types, subspecialties, and care issues During the past decade, the importance of integrating quality of life with other indicators of efficacy in cancer clinical trials has been emphasized. GD2, and CD44v6 The initial version of the Assessment came from a collaboration with the Association of Cancer Care Centers (ACCC, formerly known as the Association of Community Cancer Centers), beginning with a request for ideas from the research community regarding novel strategies and practical solutions to increase EDI in clinical trials. Over the last two decades, there has been significant focus on the clinical development of PI3K pathway Cancer Clinical Trial Eligibility Criteria: Performance Status: Clinical Trials, Clinical - Medical: Draft: Current Good Manufacturing Practice for Phase 1 Investigational Drugs: clinical trials and should require scientific justification for limited or selected study population enrollment. Immunotherapies, such as immune checkpoint inhibitors (ICIs), antibody-drug conjugates (ADCs), and targeted therapy have demonstrated significant effectiveness, marking a substantial advancement in cervical cancer The control arm of a randomized clinical trial plays a fundamental role in estimating the efficacy and safety of an investigational therapy. The difference in median age (DMA) between the trial participant Mayo Clinic Comprehensive Cancer Center offers hundreds of cancer clinical trials at our three campuses in Arizona, Florida and Minnesota and in the Midwest. For example, when a promising new therapy is being studied in early-stage clinical trials for cancer with high unmet needs, enrolling patients into control arms may cause ethical issues and unwillingness to participate[2]. A Narrative Review of Clinical Trials. Journals. Jacksonville, Fla. gov (FDA) and EMA, identified 1129 and 241 clinical trials, respectively (date of query: 2021-02-25). Dr. A Study to Evaluate Circulating Cell Free Tumor DNA as a The OncLive ® News page includes the latest in clinical oncology news, including breaking regulatory decisions, clinical trial findings, pivotal and practice-changing data published in Pfizer is committed to creating a pipeline of new cancer drugs, treatments and clinical trials that improve the outlook for cancer patients worldwide. Although OS is the definitive hard endpoint of treatment, performing clinical trials with OS as the Canadian Cancer Trials is a national, bilingual, searchable database of cancer trials in Canada. Current Oncology Clinical Trials. 2014 Mar;3(1) :2. Clinical trials are vital for developing new treatments, making sure they are safe and better than current ones. Open Clinical Trials Currently selected. Currently, the most frequent entries focusing on cancer therapies in the database of clinical trials ( www. The clinical trial guidelines for protocols (Standard Protocol Items: Recommendations for Interventional Trials–Artificial Intelligence (SPIRIT-AI) extension) and publications (Consolidated We aim to provide an overview of ongoing clinical trials involving CDK2i in the context of metastatic breast cancer (mBC), either as monotherapy or in combination with other agents. The clinical trial is still ongoing, and around 20% of patients have so far achieved a The accumulation of information in tumor biology and the development of efficient screening technologies [10], [11] has propelled oncology clinical research to the forefront of precision medicine [12]. Often, the best new information about cancer comes from animals participating in a clinical trial. The trial included some patients with pancreatic cancer, which is one of the deadliest forms of cancer. Potential solutions to overcome issues with trial design include varied methods of recruitment with flexible inclusion Colorectal Cancer. com electronic databases, as well as for abstracts from the meetings of the American Society of Clinical Oncology, American Society of Hematology, American Association for Cancer Research, and European Society for Clinical Oncology, all from their respective Istari is advancing clinical research across multiple solid tumor types with lerapolturev (formerly PVSRIPO), the only investigational immunotherapy based on the Sabin oral poliovirus vaccine. Despite an overall declining trend in the number of clinical trials in the last 5 years, we observed a transitional positive increase in the CAGR from 2020 to 2021 for trials with sites in Asia. To maximise use of the database and available information, users are advised to link to external resources, including publicly available registries, to obtain further information such as trial objectives and patient eligibility. (ASCO®) is committed to making a world of difference in cancer care. Course Structure; How to Apply; Fees & Funding; MSc Oncology by Research Projects; DPhil (PhD) in In addition to the true endpoint, overall survival (OS) surrogate endpoints—such as progression-free survival (PFS) and response rate (RR)—are considered primary endpoints for approving anticancer drugs, and clinical trial results are used to support such approval []. Treatment Trials . 16 Cunanan et al was among the first to discuss the complexities inherent to applying basket trials to oncology studies. Study with Us; MSc by Research in Oncology. Reasons for this are multifactorial and complex and include protocol, patient and sponsor factors. Search here to find a cancer clinical trial at the Odette Cancer Centre. Active Journals Find a Journal Journal Proposal Proceedings Series. Participating in clinical trials of these therapies may be the most There are six overarching recommendations: (1) clinical trials are an integral component of high-quality cancer care, and every person with cancer should have the opportunity to participate; (2) trial sponsors and investigators should design and implement trials with a focus on reducing barriers and enhancing EDI, and work with sites to conduct trials in ways that Current drug development and trial designs in neuro-oncology: report from the first American Society of Clinical Oncology and Society for Neuro-Oncology Clinical Trials Conference Lancet Oncol. Design, setting and participants Retrospective cross-sectional study included 194 pivotal trials supporting cancer drug approvals by the US FDA from 2015 to 2020. Trials for hematological cancers declined 17% in 2023, while clinical development activity for solid tumor cancers remained unchanged after a peak in 2021. Enzalutamide significantly prolonged radiographic progression-free survival and prostate-specific antigen progression; Nevertheless, ethical or feasibility issues can hinder the randomization process in oncology clinical trials. This article reviews quality-of-life assessment in clinical trial reports. Access to and participation in cancer clinical trials determine whether such data are applicable, feasible, and generalizable among populations. The clinical trials on each of these sites may be a bit different, but most trials will be on all sites. Availability and representation of race and ethnicity data by trial funding type, temporal changes in the racial/ethnic diversity of With rapid advancement in clinical research, clinical trials on breast cancer in China have made great progress and are increasingly receiving worldwide recognition. No other medical specialty to-date has had so many proposed and adopted precision medicine applications. It is Clinical trials and preclinical developments with nanobody-based diagnostics. Lone Gamrath; Tobias Bruun Pedersen; The State of Psychosocial Oncology Research on Black Canadian Affected by Cancer: A Scoping Review. It can take months, if not years, to see if a cancer treatment does what it is meant to do. Rita De Sanctis, MD, PhD, Oncologist, Assistant Professor of Medical Oncology at Humanitas University, and Consultant at Substantial therapeutic advancement has been made in the field of immunotherapy in breast cancer. Increasing trial complexity will challenge sites with narrow inclusion/exclusion criteria, multiple study arms The present study analyzed the characteristics of phase IV clinical trials in oncology using data from the ClinicalTrials. The UCD Cancer Trials Cluster is a collaborative initiative between UCD, Ireland’s largest university, St Vincent’s University Hospital, the Mater Misericordiae University Hospital, and the Cancer Clinical Research Trust. A clinical trial is one type of cancer research and helps to show if a new approach to prevention, screening, diagnosis or treatment works better than current methods. Amidst this renewed focus on diversity, it is crucial to acknowledge that Asia comprises over half of the world’s population. Cancer Clinical Trial Design Modification Biased statistical design can help in diluting the sampling bias. For example, when a promising new therapy is being studied in early-stage clinical trials for cancer with high unmet needs, enrolling patients into control arms may cause ethical issues and unwillingness to participate [2]. Dr Iasonos joined JCO in 2017 as an Associate Editor and most recently was named a Deputy Editor of the Journal, working closely with the editorial board. Younger cancer patients who filled out surveys about their symptoms experienced fewer cancer-related symptoms than those who did not complete the surveys, results from two clinical trials have shown. Existing research has highlighted a significant demographic imbalance. A clinical trial in oncology is a research study investigating the safety and effectiveness of an intervention to potentially improve outcomes for patients with cancer. Current Oncology (ISSN 1718-7729) represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy to report upon and to review progress in the management of this Given that clinical trials nursing is an emerging area of practice and that cancer clinical trials are being conducted at an increasing rate, the purpose of this study is to investigate the emergent, current, and future practice of the role of the CTN in oncology settings. 2023 Apr;24(4):e161-e171. Only a doctor can refer and enrol you in a clinical trial. Approximately 50 percent of all clinical trials started in 2022 1 were in oncology, with more than 1M patients (about the population of Delaware) needed to complete those open trials 2. Although Africa has approximately 15% of the world's population, 8 only an estimated 2% of global clinical trials are conducted in Africa. Author links open overlay panel Martha Fors Master of Applied Statistics. The Clinical Trials Database is not a registry, and therefore, it does not contain comprehensive information about each clinical trial. Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666), the Furthermore, and although early, two PROTACs targeting the androgen (ARV-110; NCT03888612) and estrogen (ARV-471; NCT05654623) receptors have entered phase II and III trials for prostate cancer and breast cancer, respectively, underscoring the potential clinical utility of PROTACs as a novel therapeutic strategy in cancer . Topics include targeted therapies; mechanisms of drug sensitivity and resistance; pharmacogenetics and pharmacogenomics; personalized medicine; immunotherapy; gene therapy; diagnostic biomarkers; innovative Cancer clinical trials can take years to complete. Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cell therapy (ACT), which collects infiltrating lymphocytes at the tumor site and expands them in vitro to obtain TIL Objective To examine factors associated with accrual rate in industry sponsored clinical trials supporting US Food and Drug Administration (FDA) cancer drug approvals from 2015 to 2020. Combining HIF inhibitors with current cancer therapies to increase anti-tumor activity and diminish treatment resistance is one strategy for combating therapeutic resistance. The findings show patient-reported outcome (PRO) surveys for children can give an accurate picture of how a child is feeling during the stress of treatment. 53 The primary endpoint was progression-free survival (PFS) at 6 months. Share, save or print the trial details and review them with your doctor or healthcare team. Ghizlène Sehabi; Therefore, basket trials pose challenges to the traditional paradigm for trial design and analysis, which assumes that individual patients who enroll in the same clinical study can be averaged. and clinical trials involving Aurora kinase inhibitors, with particular emphasis on published early phase studies, and the observed anti-tumor activity of these agents. In this article, we will introduce the current status of the region's clinical research in cancer, with a special focus on academic cancer research groups Initially reported in Journal of Clinical Oncology in 2019, 1 the ARCHES trial compared the addition of enzalutamide or placebo with androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer (mHSPC). By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal serves all those involved in the diagnosis, treatment, management, and prevention of cancer. 68, 70, 81, 82, 83, 87, 97 Abstract. 2015 Dec;42(6):832-48. In a 2019 whitepaper,8 a Friends of Cancer Research working group provided extensive descriptions of key design and analysis elements of trials that incorporate external control data, common limitations and pitfalls arising for unmitigated biases, as well as a case study Oncology will endure as a dominant therapeutic area in clinical research in 2023. 9 A review of the National Institutes of Cancer research is an important part of cancer care and over the years has let to better treatments and outcomes for people diagnosed with cancer. Access cutting-edge cancer treatments. There are two types of clinical studies: interventional studies (also called clinical trials) and observational studies. These trials test new treatments or new ways > Current Trials. While no approved oligonucleotide drug currently exists for any type of cancer, results obtained in preclinical studies and clinical trials are encouraging. Cancer Trials Ireland, RCSI House, 121 St Stephen's The American Cancer Society estimated that there would be 288,300 new cases of prostate cancer and 34,700 deaths from prostate cancer in the United States in 2023. The trial will explore if the Cytosponge, a ‘sponge-on-a-string' test for Barrett’s oesophagus developed by Fitzgerald, can prevent deaths from oesophageal cancer when offered as a screening test to people on long-term medication for heartburn – one of the most common Barrett’s oesophagus symptoms. . Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress Semin Oncol. Below are some examples of what our researchers Clinical trials in oncology are the engine that drives progress in cancer therapeutics and are integral to quality oncological care. 2016. Overall, these studies indicate the value of Nbs in the field of oncology and show where Nbs can complement current cancer patient management. Approved Cancer Drug Therapies Based on Nanotechnology (EMA: European Medicines Agency; FDA: US Food and Drug Administration; Adapted from Andreas Wicki, et al. All new cancer treatments are tested in clinical trials. Eradicating MRD in patients with AML prior to Stem Cell Transplant (ERASE) For better use of external controls in oncology clinical trials, we recommend: prospective study designs to avoid selection bias, sufficient baseline data to ensure the comparability of study populations, consistent endpoint measurements to enable outcome comparison, robust statistical methodology for comparative analysis, and collaborative efforts of sponsors and regulators to The number of older adults living with cancer is increasing. Interests: pancreatic cancer; clinical research; surgery; translational research; The Victorian Cancer Trials Link connects people affected by cancer and their clinicians with information about current cancer clinical trials in Victoria, Australia. Efforts to increase the efficiency and interpretability of clinical trials within the neuro-oncology community have focused on standardization of response assessment, development of consensus guidelines for clinical trial Current Oncology Reports - This review will discuss the challenges facing chimeric antigen receptor (CAR)-T cell application for solid tumors and opportunities to overcome these obstacles. The scientific basis underlined is analyzed. For Patients with Purpose The purpose of the trial is to assess the clinical efficacy of adagrasib treatment in patients with KRASG12C-mutant NSCLC, in patients who are elderly (≥70 years) or those with poor performance status (ECOG PS=2). Enzalutamide significantly prolonged radiographic progression-free survival and prostate-specific antigen progression; Patients 70 years of age or older represent 42% of the overall cancer population. 42 The authors also elucidated the scope of potential The current design of oncology phase I clinical trials: progressing from algorithms to statistical models Chin Clin Oncol. Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine against HIV to artificial intelligence tools for lung cancer and patient triage. Such trials help scientists answer questions about new cancer therapies, including: what diseases should they be used for? In this work, Unger et al 6 examine the rates of clinical trial enrollment using the data from the Commission on Cancer, 7 with a goal of generating a better understanding of current trends in cancer clinical trial enrollment. Finally, we discuss lessons learned from Current Oncology Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. Our strong pipeline—one of the most robust in the industry—includes biologics, small molecules, immunotherapies, and biosimilars, and is centered on exploring a wide array of How to find the Early Phase Clinical Trials Unit; FAQs; Further Information; Oncology Clinical Trials Office. The IGI has tracked the progress of CRISPR clinical trials since they first began, and this milestone has been Oncology research and development has seen an increasing focus on targeted drugs with innovative mechanisms of action for treatment of cancers over the last decade. , The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials. More >> Planned Trials . 022. All searched clinical trials were included in the current status analysis of clinical trials on cancer. Speak to a care advisor. Search for a clinical trial by cancer type, province, drug, keyword, or phrase. Current Trials. Clinical trials. cancer therapeutic research has largely shifted from a focus on cytotoxic agents to newer drugs that act through inhibiting cancer cell growth and survival mechanisms while protecting healthy cells to the extent possible [7]. 1016/S1470-2045(23)00005-0. Years of research exploring mRNA vaccines for cancer treatment in preclinical and clinical trials have set the stage for the rapid development of mRNA vaccines during the COVID-19 pandemic. Cancer ranks as a leading cause of death and an important barrier to increasing life expectancy globally, accounting for nearly 10 million deaths in 2020. Through research, education, and The way Oncology clinical trials are designed and performed has changed over time. Learn more The Canadian Cancer Trials Group (CCTG) is a cooperative oncology group that designs and administers clinical trials in cancer therapy, supportive care and prevention across Canada. A Phase 1b/2, Randomized, Open-Label Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus This oncology research from the IQVIA Institute profiles the current state of research and development in oncology, including key mechanisms, targets and cancer types being investigated as well as pointing Methods: Seventy-two global phase III and IV prevention, screening, and treatment prostate cancer clinical trials with enrollment start dates between 1987 and 2016 were analyzed in this study, representing a total of 893,378 individual trial participants. Cancer research that involves people, or data or samples from people, is called cancer clinical research. 5. , chair of Investigational Cancer Therapeutics. Oncology Clinical Trials Office. His professional interests include clinical and pre-clinical research focused on breast cancer. 08. Pfizer Oncology is committed to discovering, investigating, and developing transformative therapies that improve the outlook for cancer patients worldwide. seminoncol. Potential solutions to overcome issues The ability of clinical trial sites to operate efficiently and adapt quickly to sponsor needs is crucial for successful trial execution. Name No. gov database focused on Oncology trials with a Bayesian approach in their design. Clinical trials are also a treatment option beyond The Journal is especially interested in clinical trials evaluating new treatments, accompanied by research on pharmacology, and molecular alterations or biomarkers that Current status of Bayesian clinical trials for oncology, 2020. S. com, and Molecularmatch. gov registry. Concurrently randomized control arms allow for an understanding of the temporally relevant factors associated with the natural history of the disease, particularly with respect to current standards of clinical care. design of oncology clinical trials that incorporate external control data. According to WCG’s 2024 Clinical Research Site Challenges Report, a common hurdle is the need for improved communication and streamlined collaboration between sponsors and sites. 2. Although we are making considerable progress in the fight against cancer, we still have a long way to go. Clinical Cancer Research publishes articles that focus on innovative clinical and translational research bridging the laboratory and the clinic. Clinical trials are scientific studies in which new treatments – drugs, diagnostic procedures, and other therapies – are tested in patients to determine if they are safe and effective. we aimed to characterize the main characteristics of Bayesian Oncology Clinical trials in ClinicalTrials. “It’s also an opportunity for patients to access otherwise The CCTG ES3 NEEDS international esophageal cancer clinical trial is now opened in Canada. 57 Indeed, a major step in this direction was taken up in 2020 when the NCG of 11 centers was set up to General cancer clinical trial listings. Annually, the program manages an average of 30 clinical trials to study more effective therapies for a variety of cancer types including, osteosarcoma, lymphoma, soft tissue sarcoma, and brain Immunotherapies, mainly immune checkpoint inhibitors (ICIs), have revolutionized cancer treatment strategies over the past decade, but their limitations have limited clinical applications. 1 The Data from the Chinese Clinical Trial Registration show that 71% of trials were sponsored by academic institutions. Phases of Our clinical trials recruit around 20,000 patients on average every year. Studies like these have led to discoveries such as new medicines to treat cancer, new therapies to reduce the side effects of cancer or its treatment, and lifestyle changes people can make to lower chances of getting cancer. Search Search Most current clinical trials on miRNAs (101 of 108) aim to discover novel cancer biomarkers or indicators of drug sensitivity (Supplementary Materials, miRNA screening). treatment sensitizing effects in combination with gemcitabine and/or PD-1 antibody in pre-clinical models of pancreatic cancer . The FDA reviews the results Introduction There has been a growing recognition on the importance of diversity in clinical trials. Case 1; Case 2; Case 3; Case 4; Case 5; Case 6; Case 7; Case 8 Recent clinical trials have yielded promising results for the development of systemic therapies for advanced cervical cancer. Older-age-selected studies are desirable, but their characteristics and overall performance are unknown. In a phase I clinical trial in solid tumors (n = 125), dubermatinib was tolerated with . gov ) include the terminologies stem cell, targeted therapy, immunotherapy, and gene therapy because they are very promising and effective. ALC9. Lerapolturev has been administered to more than 200 patients and is Below are current clinical trials. 2015. The unique identification code given to each clinical study upon registration at ClinicalTrials. The study is investigating whether delaying surgery for patients with squamous cell carcinoma of the esophagus is as good as the current treatment. Then, we review the current state of clinical trials of these agents for different types of cancer and outcomes from published data. 14 Academic sponsors include hospitals and institutions themselves (eg, the Beijing Hope Run raises funds Find a clinical trial in cancer treatment at Princess Margaret Cancer Centre. The number of older adults living with cancer is increasing. Volume 43; Issue 2; January 10, 2025; Founded in 1964, the American Society of Clinical Oncology, Inc. gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. Panel D shows the major immune The tumor objective response rate (ORR) is an important parameter to demonstrate the efficacy of a treatment in oncology. BC Cancer – Abbotsford; BC Cancer – Kelowna; BC Cancer – Prince George; BC Cancer – Surrey; BC Cancer – Vancouver; BC Cancer – Victoria; PET/CT Clinical Trials; Education & Development. Around 30% of the trials investigate miRNAs that have previously been identified to show altered expression in cancer and the remaining 70% intend to find novel miRNA signatures for diagnostic use ( AbstractBackground:. Most cancer clinical trials are treatment studies that involve people who have cancer. Interventions Clinical We searched for these published articles in the Medline, Embase, Clinicaltrials. The ideal Current Oncology Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. 447 studies in Oncology (Medical) (open studies only). There is a clear lack of representation of older adults in clinical trials, including cancer trials. Although there are considerable racial and ethnic disparities in prostate cancer incidence and mortality in the United States and globally, clinical trials often do not reflect disease incidence across racial and ethnic subgroups. This issue seeks to explore the latest developments in early-phase and late-phase trial design, adaptive A clinical trial in oncology is a research study investigating the safety and effectiveness of an intervention to potentially improve outcomes for patients with cancer. 4–6 Only 24% of participants in trials registered with the US Food & Drug Administration (FDA) are 70 years or older, 4–6 and fewer than 10% of patients in this Current Issue. Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State of the Progress In a phase II clinical trial, 64 patients with platinum-resistant ovarian cancer were given a 160 mg/m 2 oral dose of ENMD-2076 once daily. Available 24 hours a day, 7 The link ClinicalTrials. Find an NCI-supported clinical trial—and learn how to locate other research studies—that may be right for Below are current clinical trials. Authors At light of the current research and preliminary clinical findings a bunch of open questions bends over novel CDK2i. Addressing these challenges requires building a Oncology Drug Pipeline & Cancer Clinical Trials. 1053/j. 2016 Nov:50:35-47. Aurora kinase inhibitors have demonstrated anti-tumor activity in multiple tumor types in clinical trials, including responses seen in AML,71, 72, 74 CML,88, 89 prostate cancer, 83 and ovarian cancer. 09. The immune checkpoint inhibitor pembrolizumab in combination with chemotherapy received FDA approval for both PD-L1 positive metastatic and early-stage triple-negative breast cancer, while ongoing clinical trials seek to expand the current treatment Clinical trials are research studies that evaluate a new drug or treatment to make sure that it is safe and effective for patients. gqlkmw ckn prontiu avzuf uyrcv pitzdxn tocbu dnd ddj ecgb